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Catalytic reduction reactions using isopropanol(IPA) as a transfer hydrogenating agent are gaining significant attention due to the low cost and large-scale production of IPA. Traditional methods for carbon-carbon(C—C) bond construction often rely on expensive and scarce transition metal catalysts, raising concerns about sustainability and environmental impact. To address these challenges, we develop a bifunctional photocatalyst, phloroglucinol carbon quantum dot(PG-CQD). It facilitates catalytic transfer hydrogenation(CTH) with IPA as the hydrogen donor. PG-CQDs exhibit both dehydrogenation and reduction activities, enabling the formation of vicinal diols under mild conditions with visible light irradiation. We propose a CTH mechanism that has been successfully validated through experiments. The catalytic system demonstrates remarkable versatility, enabling the synthesis of various vicinal diols from diverse α-keto ester substrates with good or excellent yields. These findings offer a sustainable synthetic strategy that aligns with green chemistry principles and establish a promising pathway for the development of environmentally benign and energy-efficient organic transformations.
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Basic Information:
DOI：10.19884/j.1672-5220.202504002
China Classification Code:O621.251
Citation Information:
[1]CHEN Di,WANG Le.Photoinduced Electron Transfer-Driven Reductive Coupling of α-Keto Esters for Efficient Carbon-Carbon Bond Construction[J].Journal of Donghua University (English Edition),2026,43(01):1-9.DOI:10.19884/j.1672-5220.202504002.
Fund Information:
National Natural Science Foundation of China (Nos. 21902023 and 21901252); Shanghai Pujiang Program,China (No. 19PJ1400300); Professor of Special Appointment (Eastern Scholar),China; Shanghai Institutions of Higher Education Fundamental Research Funds for the Central Universities,China (No. 0900000155)
2026-02-27
2026-02-27
2026-02-27